Over the last four decades, the evidence about the influences that built-up spaces exert on the health of those who occupy them have been growing. Despite the difficulties and controversies that have arisen along this path, today health and well-being are considered basic indicators of sustainability for the building sector in the EU. However, an up-to-date and rigorous approach to health understood as “a state of complete physical, mental and social well-being, and not only the absence of affections or diseases”, as established by the WHO in 1948, makes it necessary to reconsider the spheres of influence of the built spaces. An open debate on what is coming to us and a presentation of a report on health from the Green Building Council Spain that has taken more than 2 years in its writing.